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KMID : 1129720080250020211
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Korean Journal of Acupuncture
2008 Volume.25 No. 2 p.211 ~ p.224
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Hepatoprotective effect of electroacupuncture at GB34 (Yangreungcheon) in CCl₄-intoxicated rats
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Chae Choong-Heon
Ahn Taek-Won
Yim Yun-Kyoung
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Abstract
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Objectives: To investigate the effect of electro-acupuncture (EA) at GB34 on hepatotoxicity in CCl₄-intoxicated rats.
Methods: Rats were injected with CCl₄ and treated with acupuncture or 2 Hz electro-acupuncture (EA) at left GB34 three times a week for 10 weeks. A non-acupoint in left gluteal area was selected as a sham point. To estimate the effects of EA on hepatotoxicity in rats, body weight, liver weight and liver index were measured, and biochemical assays for serum ALT, AST, ALP and total cholesterol, and hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils and monocytes, and histology analysis of liver tissue were performed.
Results: 1. Lymphocyte level in blood was significantly decreased by CCl₄-intoxication and significantly increased by acupuncture and 2 Hz EA at left GB34. 2. Neutrophill and monocyte level in blood was increased by CCl₄-intoxication and significantly reduced by acupuncture and 2 Hz EA at left GB34. 3. Acupuncture and 2 Hz EA at left GB34 significantly reduced serum ALT and AST which were increased by CCl₄-intoxication. 4. EA at GB34 significantly reduced serum ALT and AST as compared with EA at sham point in -intoxicated rat. 5. No significant difference was found between the effects of acupuncture and that of 2 Hz EA on CCl₄-induced liver damage in rats.
Conclusions: 2 Hz EA at GB34 has hepatoprotective effects on CCl₄-induced liver damage in rats and the point-specificity of GB34 may be involved in these effects.
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KEYWORD
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Electro-acupuncture, GB34CCl₄, Liverdamage
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